Ion Selectivity of α-Hemolysin with a β-Cyclodextrin Adapter. I. Single Ion Potential of Mean Force and Diffusion Coefficient
نویسندگان
چکیده
منابع مشابه
Prolonged Residence Time of a Noncovalent Molecular Adapter, β-Cyclodextrin, within the Lumen of Mutant α-Hemolysin Pores
Noncovalent molecular adapters, such as cyclodextrins, act as binding sites for channel blockers when lodged in the lumen of the alpha-hemolysin (alphaHL) pore, thereby offering a basis for the detection of a variety of organic molecules with alphaHL as a sensor element. beta-Cyclodextrin (betaCD) resides in the wild-type alphaHL pore for several hundred microseconds. The residence time can be ...
متن کاملIon-Specific Potential of Mean Force Between two Aqueous Proteins
There is a considerable effort in the literature trying to calculate the mean force between globular proteins (and colloidal particles). To this purpose, we used here the ion-specific Poisson-Boltzmann (PB) equation that presents good results of ionic concentration profiles around a macroion, especially for salt solutions containing monovalent ions. The ion-specific PB equation includes not onl...
متن کاملPotential of Mean Force of Ion Permeation through alpha7 nAChR Ion Channel
Many neuronal diseases such as Alzheimer’s dementia are related to a loss of inter-neuron communication. The nicotinic acetylcholine receptor (nAChR) plays a crucial role in this process and is severely affected upon disease progression. Successful therapy approaches rely on modulation of response signals, initiated by the flux of ions through the receptor integrated ion channel at the post-syn...
متن کاملa comparison of teachers and supervisors, with respect to teacher efficacy and reflection
supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...
15 صفحه اولfabrication of new ion sensitive field effect transistors (isfet) based on modification of junction-fet for analysis of hydronium, potassium and hydrazinium ions
a novel and ultra low cost isfet electrode and measurement system was designed for isfet application and detection of hydronium, hydrazinium and potassium ions. also, a measuring setup containing appropriate circuits, suitable analyzer (advantech board), de noise reduction elements, cooling system and pc was used for controlling the isfet electrode and various characteristic measurements. the t...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2009
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp906790f